Side-by-side comparisons of the top 50 most expensive drugs by NADAC unit cost. Compare pricing, generic vs brand status, OTC availability, and pharmacy types across 1,225 drug pairs.
All data sourced from CMS NADAC & Medicare Part D (2026). Prices are pharmacy acquisition costs, not retail.
Prices shown are NADAC (National Average Drug Acquisition Cost) values from CMS. These represent what pharmacies pay to acquire each medication. Your actual cost depends on insurance, pharmacy markup, and dispensing fees.
Comparing drugs helps identify whether generic alternatives exist at lower prices and understand relative cost differences between medications.