Most Expensive Drugs in America

Top 100 drugs ranked by NADAC (National Average Drug Acquisition Cost) unit price. These are the prices pharmacies pay to acquire the medication, before any markup or insurance.

#	Drug Name	Type	Rx/OTC	Avg Price	Unit
1	STELARA 90 MG/ML SYRINGE	Brand Name	Rx	$24,599.06	ML
2	SKYRIZI 150 MG/ML SYRINGE	Brand Name	Rx	$17,835.55	ML
3	SKYRIZI 150 MG/ML PEN	Brand Name	Rx	$17,642.38	ML
4	TREMFYA 100 MG/ML INJECTOR	Brand Name	Rx	$12,239.52	ML
5	SIMPONI 50 MG/0.5 ML PEN INJEC	Brand Name	Rx	$10,843.33	ML
6	AVONEX PREFILLED SYR 30 MCG KIT	Brand Name	Rx	$7,341.09	EA
7	AVONEX PEN 30 MCG/0.5 ML KIT	Brand Name	Rx	$7,309.73	EA
8	LUPRON DEPOT 22.5 MG 3MO KIT	Brand Name	Rx	$5,399.92	EA
9	CIMZIA 2X200 MG/ML SYRINGE KIT	Brand Name	Rx	$4,944.14	EA
10	LUPRON DEPOT 11.25 MG 3MO KIT	Brand Name	Rx	$4,546.75	EA
11	INVEGA TRINZA 819 MG/2.63 ML	Brand Name	Rx	$3,496.92	ML
12	INVEGA TRINZA 546 MG/1.75 ML	Brand Name	Rx	$3,487.58	ML
13	INVEGA TRINZA 410 MG/1.32 ML	Brand Name	Rx	$3,435.14	ML
14	COSENTYX (150 MG/ML) 300 MG DOSE-2 PENS	Brand Name	Rx	$3,133.71	ML
15	HUMIRA(CF) 40 MG/0.4 ML SYRINGE	Brand Name	Rx	$3,123.51	EA
16	HUMIRA(CF) PEN 40 MG/0.4 ML	Brand Name	Rx	$3,121.75	EA
17	HUMIRA 40 MG/0.8 ML SYRINGE	Brand Name	Rx	$3,121.27	EA
18	HUMIRA PEN 40 MG/0.8 ML	Brand Name	Rx	$3,119.47	EA
19	HUMIRA PEN PSORIASIS-UVEITIS-ADOL HS STARTER 40 MG/0.8 ML	Brand Name	Rx	$3,115.30	EA
20	HUMIRA PEN CROHN'S-UC-HS STARTER 40 MG/0.8 ML	Brand Name	Rx	$3,115.25	EA
21	GVOKE HYPOPEN 2PK 0.5 MG/0.1 ML	Brand Name	Rx	$2,853.59	ML
22	ABILIFY MAINTENA ER 400 MG VL	Brand Name	Rx	$2,445.84	EA
23	ABILIFY MAINTENA ER 400 MG SYR	Brand Name	Rx	$2,444.19	EA
24	ANNOVERA VAGINAL RING	Brand Name	Rx	$2,216.29	EA
25	INVEGA SUSTENNA 156 MG/ML SYRG	Brand Name	Rx	$2,050.54	ML
26	INVEGA SUSTENNA 234 MG/1.5 ML	Brand Name	Rx	$2,046.65	ML
27	INVEGA SUSTENNA 117 MG/0.75 ML	Brand Name	Rx	$2,046.17	ML
28	INVEGA SUSTENNA 78 MG/0.5 ML	Brand Name	Rx	$2,042.00	ML
29	PERSERIS ER 90 MG POWDER SYRNG	Brand Name	Rx	$1,879.84	EA
30	PERSERIS ER 90 MG SYRINGE KIT	Brand Name	Rx	$1,879.84	EA
31	ABILIFY MAINTENA ER 300 MG VL	Brand Name	Rx	$1,834.87	EA
32	ABILIFY MAINTENA ER 300 MG SYR	Brand Name	Rx	$1,827.31	EA
33	LUPRON DEPOT 7.5 MG KIT	Brand Name	Rx	$1,794.46	EA
34	ENBREL 50 MG/ML SURECLICK	Brand Name	Rx	$1,599.63	ML
35	ENBREL 25 MG/0.5 ML SYRINGE	Brand Name	Rx	$1,597.43	ML
36	ENBREL 50 MG/ML MINI CARTRIDGE	Brand Name	Rx	$1,596.93	ML
37	ENBREL 50 MG/ML SYRINGE	Brand Name	Rx	$1,596.90	ML
38	FORTEO 600 MCG/2.4 ML PEN INJ	Brand Name	Rx	$1,596.70	ML
39	LUPRON DEPOT 3.75 MG KIT	Brand Name	Rx	$1,505.48	EA
40	VIVITROL 380 MG VIAL	Brand Name	Rx	$1,446.85	EA
41	VIVITROL 380 MG VIAL-DILUENT	Brand Name	Rx	$1,446.85	EA
42	DUPIXENT 200 MG/1.14 ML SYRING	Brand Name	Rx	$1,443.87	ML
43	REBIF 44 MCG/0.5 ML SYRINGE	Brand Name	Rx	$1,441.54	ML
44	PROLIA 60 MG/ML SYRINGE	Brand Name	Rx	$1,428.42	ML
45	GVOKE HYPOPEN 1-PK 1 MG/0.2 ML	Brand Name	Rx	$1,427.39	ML
46	GVOKE PFS 1-PK 1 MG/0.2 ML SYR	Brand Name	Rx	$1,426.19	ML
47	GVOKE PFS 2-PK 1 MG/0.2 ML SYR	Brand Name	Rx	$1,424.86	ML
48	GVOKE HYPOPEN 2-PK 1 MG/0.2 ML	Brand Name	Rx	$1,423.08	ML
49	TYMLOS 80 MCG DOSE PEN INJECTR	Brand Name	Rx	$1,413.23	ML
50	REBIF 22 MCG/0.5 ML SYRINGE	Brand Name	Rx	$1,400.93	ML
51	ORENCIA 125 MG/ML SYRINGE	Brand Name	Rx	$1,231.29	ML
52	ORENCIA CLICKJECT 125 MG/ML	Brand Name	Rx	$1,230.50	ML
53	RISPERDAL CONSTA 50 MG VIAL	Brand Name	Rx	$1,072.26	EA
54	TERIPARATIDE 620 MCG/2.48 ML	Generic	Rx	$996.60	ML
55	NORDITROPIN FLEXPRO 10 MG/1.5	Brand Name	Rx	$945.57	ML
56	ARISTADA ER 441 MG/1.6 ML SYRN	Brand Name	Rx	$871.17	ML
57	ARISTADA ER 882 MG/3.2 ML SYRN	Brand Name	Rx	$871.02	ML
58	ARISTADA ER 662 MG/2.4 ML SYRN	Brand Name	Rx	$870.79	ML
59	ARISTADA ER 1,064 MG/3.9 ML SYR	Brand Name	Rx	$860.02	ML
60	DUPIXENT 300 MG/2 ML PEN	Brand Name	Rx	$818.62	ML
61	DUPIXENT 300 MG/2 ML SYRINGE	Brand Name	Rx	$818.30	ML
62	RISPERDAL CONSTA 37.5 MG VIAL	Brand Name	Rx	$803.27	EA
63	ENBREL 25 MG KIT	Brand Name	Rx	$726.85	EA
64	FEMRING 0.10 MG/DAY VAG RING	Brand Name	Rx	$712.28	EA
65	GENOTROPIN 5 MG CARTRIDGE	Brand Name	Rx	$678.53	EA
66	AIMOVIG 140 MG/ML AUTOINJECTOR	Brand Name	Rx	$675.06	ML
67	AIMOVIG 70 MG/ML AUTOINJECTOR	Brand Name	Rx	$674.94	ML
68	FEMRING 0.05 MG/DAY VAG RING	Brand Name	Rx	$664.72	EA
69	WEGOVY 0.25 MG/0.5 ML PEN	Brand Name	Rx	$657.38	ML
70	WEGOVY 1 MG/0.5 ML PEN	Brand Name	Rx	$648.39	ML
71	WEGOVY 0.5 MG/0.5 ML PEN	Brand Name	Rx	$647.18	ML
72	BYETTA 5 MCG DOSE PEN INJ	Brand Name	Rx	$641.27	ML
73	EMGALITY 120 MG/ML PEN	Brand Name	Rx	$631.97	ML
74	EMGALITY 120 MG/ML SYRINGE	Brand Name	Rx	$630.62	ML
75	BETASERON 0.3 MG KIT	Brand Name	Rx	$602.97	EA
76	SANCUSO 3.1 MG/24 HR PATCH	Brand Name	Rx	$591.02	EA
77	OZEMPIC 0.25-0.5 MG/DOSE (2 MG/1.5 ML) PEN	Brand Name	Rx	$571.53	ML
78	EMVERM 100 MG TABLET CHEW	B-ANDA	Rx	$538.55	EA
79	RISPERDAL CONSTA 25 MG VIAL	Brand Name	Rx	$535.80	EA
80	EMGALITY 300 MG DOSE (100 MG/ML X 3 SYRINGES)	Brand Name	Rx	$524.70	ML
81	PROCRIT 20,000 UNITS/ML VIAL	Brand Name	Rx	$520.60	ML
82	SPRYCEL 100 MG TABLET	Brand Name	Rx	$510.80	EA
83	ESTRING 2 MG VAGINAL RING	Brand Name	Rx	$483.54	EA
84	COPAXONE 40 MG/ML SYRINGE	Brand Name	Rx	$473.36	ML
85	MOUNJARO 12.5 MG/0.5 ML PEN	Brand Name	Rx	$468.25	ML
86	MOUNJARO 7.5 MG/0.5 ML PEN	Brand Name	Rx	$467.79	ML
87	MOUNJARO 15 MG/0.5 ML PEN	Brand Name	Rx	$467.62	ML
88	MOUNJARO 5 MG/0.5 ML PEN	Brand Name	Rx	$467.55	ML
89	MOUNJARO 2.5 MG/0.5 ML PEN	Brand Name	Rx	$467.37	ML
90	MOUNJARO 10 MG/0.5 ML PEN	Brand Name	Rx	$467.27	ML
91	NORDITROPIN FLEXPRO 5 MG/1.5	Brand Name	Rx	$465.30	ML
92	AIRDUO DIGIHALER 232-14 MCG	Brand Name	Rx	$453.89	EA
93	WEGOVY 2.4 MG/0.75 ML PEN	Brand Name	Rx	$431.80	ML
94	WEGOVY 1.7 MG/0.75 ML PEN	Brand Name	Rx	$431.69	ML
95	AJOVY 225 MG/1.5 ML SYRINGE	Brand Name	Rx	$429.27	ML
96	AJOVY 225 MG/1.5 ML AUTOINJECT	Brand Name	Rx	$427.57	ML
97	TRULICITY 4.5 MG/0.5 ML PEN	Brand Name	Rx	$426.10	ML
98	TRULICITY 3 MG/0.5 ML PEN	Brand Name	Rx	$426.02	ML
99	TRULICITY 0.75 MG/0.5 ML PEN	Brand Name	Rx	$425.67	ML
100	TRULICITY 1.5 MG/0.5 ML PEN	Brand Name	Rx	$425.63	ML

About This Data

Prices shown are NADAC (National Average Drug Acquisition Cost) values — the average price pharmacies pay to acquire each drug. This data comes from the Centers for Medicare & Medicaid Services (CMS) and is based on monthly surveys of retail pharmacies across the United States.

The actual price you pay at the pharmacy will be higher due to pharmacy markup, dispensing fees, and your insurance plan's cost-sharing structure. Use this data as a baseline for understanding relative drug costs.

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